Cisplatin and kidney damage

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August undefined, 2024

WebCisplatin is an effective chemotherapeutic agent, but significant nephrotoxicity limits its clinical use. Despite extensive investigation of the acute cellular and molecular … WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or …

Cisplatin Cancer information Cancer Research UK

WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and … WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and … lit outdoor christmas trees

The use of cisplatin in patients after kidney... : Medicine

WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has … WebAug 6, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. WebAug 24, 2024 · Damage to non-cancer cells can occur while the body works to metabolize and excrete the drug. “Although the body excretes 50% to 80% of the administered cisplatin within a day or so, some remains in the kidney, where it damages specific cells in the nephron, which removes waste from the blood before it is converted to urine,” Dr. Zhao … litouws basketbalteam

Cisplatin Cancer information Cancer Research UK

Yale Scientists Seek to Shift Treatment of Kidney Damage

WebNov 12, 2024 · Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.Nausea and Vomiting: cisplatin injection can cause severe … WebCisplatin and kidney damage Kent Cass Member Posts: 1,898 Member January 2010 edited March 2014 #1 The subject of kidney damage as a result of chemo by Cisplatin … litouwen a lygaWebDec 21, 2024 · Cisplatin is a potent first-line of chemotherapeutic drug for treating various neoplasms, but its administration in hospital settings is hampered due to its untoward nephrotoxicity. Previous investigations indicated that about 30% of cisplatin-treated patients (at the dose of 50–100 mg/m 2) developed AKI [ 7 ]. lit outlet cover

"WebApr 10, 2024 · Interestingly, TGF-β-targeting strategies did not block cisplatin-induced NET formation in the kidney and did not reduce cisplatin-induced kidney damage, suggesting that the effects of NETs on kidney injury are not TGF-β dependent (Figures S5X–S5AA and Table 1). Altogether, these results indicate that NETs induce a TGF-β-dependent EMT in ... " - Cisplatin and kidney damage

Cisplatin and kidney damage

Exploring the Metabolic Differences between Cisplatin

WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [ 29, 30 ]. In addition, nicotinamide prevents apoptosis in different cellular injury paradigms [ 31 ]. WebMay 8, 2024 · Serum Creatinine (SCr)-Acute Kidney Injury (AKI) Staging Outlined by the Kidney Disease: Improving Global Outcomes (KDIGO) Guidelines and Electrolyte-AKI (eAKI) Grading Based on National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 4 eTable 2.

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WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebFeb 16, 2024 · Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys. Call your doctor if you have a fever, mouth sores, …

WebMar 9, 2024 · Cisplatin is mainly excreted through the kidneys. It becomes concentrated during excretion, and the concentration in renal tubular epithelial cells is much higher …

WebCisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, ... As opposed to immune-mediated CIT, the release of ROS occurs downstream in the signalling pathway of cisplatin-induced damage in healthy cells. Because the significance of ROS as the damage-causing agent has been established in CIT, it is only … WebMar 29, 2024 · In cisplatin-treated wildtype mice, there were increases in biomarkers of CIAKI, in addition to histological indication of kidney damage such as tubule dilation and …

WebTubular epithelial cells (TECs) is one of the most damaged cells in cisplatin induced AKI ( Xu et al., 2015 ). The well-known mechanism by which cisplatin exerts its anticancer effects—DNA damage—also affecting renal cells ( Tchounwou et al., 2024 ).

WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … litovich v bank of americaWebApr 25, 2014 · The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in … litouws alfabetWebwww.ncbi.nlm.nih.gov litovel firmyWebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various intracellular stresses, including DNA damage,... Multiple stress responses, including … litovwpled40k120pedbhp17WebMay 8, 2024 · Nephrotoxicity With Cisplatin Patients may accumulate metabolites in the renal proximal tubule cells of the kidneys, where 90% of cisplatin undergoes urinary excretion, Duffy et al. explained. This causes a trifecta of factors: direct inflammation, production of reactive oxygen species leading to oxidative cell damage, and cell death. litouwen informatieWebOct 22, 2024 · As repeated injections of 6 mg/kg cisplatin in a one-week interval did not cause apparent kidney injury and those of 10 mg/kg cisplatin accelerated kidney injury without causing lethality,... lit oversized sweatshirtWebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for patients with eGFR from 50 to 59.9 mL/min may result in a higher cumulative dose of cisplatin without higher renal toxicity, whic … litoweb carpi