Cisplatin chemistry

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August undefined, 2024

WebThe shape of the cisplatin molecule is square and flat. Its covalent bonds readily exchange with other ligands, including even water. In the aqueous environment of the body, the … WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma …

Cisplatin Podcast Chemistry World

Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… WebOne of the first known coordination compounds was Peyrone’s Chloride (also known as cis-diamminedichloroplatinum (II), or cis-DDP), first reported in 1845. This compound … high rise apartment amenities

trans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 - PubChem

WebThe antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxopl … Pt(IV) complexes as prodrugs for cisplatin WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products. WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … how many calories in a thin slice of turkey

Precisely Assembled Nanoparticles against Cisplatin Resistance via ...

Exploring the Metabolic Differences between Cisplatin- and UV …

WebIntroduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, … how many calories in a tiger baguetteWebOne of the first known coordination compounds was Peyrone’s Chloride (also known as cis-diamminedichloroplatinum (II), or cis-DDP), first reported in 1845. This compound was not fully understood until 1893, when Alfred Werner deduced its structure and described cis-DDP and its trans isomer in a landmark paper. how many calories in a timbit donut

"WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° … " - Cisplatin chemistry

Cisplatin chemistry

WebJun 20, 2024 · Cisplatin [ cis- diamminedichloroplatinum (II) ( cis -DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of solid tumors ( 1 – 3 ), including neuroblastoma ( 4 ), the extracranial neoplasm most commonly diagnosed in childhood ( 5 ). Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ...

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WebThe reactions of cisplatin [cis-diamminedichloroplatinum (II), CDDP] with glutathione (GSH) and drug thiols were investigated at 37 degrees C in 100 mM Tris-NO (3), pH approximately 7.4, using a clinically relevant concentration of CDDP (33 micro M), a large excess of GSH (16.5 mM), and [NaCl] of 4.62 mM. WebCisplatin: chemistry, distribution and biotransformation Authors D F Long , A J Repta PMID: 7016212 DOI: 10.1002/bdd.2510020102 Abstract A review of the use of cisplatin …

WebCisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug Wiley 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most … WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, …

WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. [2] It is given by injection into a vein. [2] WebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. …

WebCisplatin / chemistry Cisplatin / metabolism* Colonic Neoplasms / metabolism* Colonic Neoplasms / pathology Copper / metabolism Copper / pharmacokinetics Copper Transporter 1 Dose-Response Relationship, Drug Homeostasis Humans Platinum / metabolism Platinum / pharmacokinetics Structure-Activity Relationship Substances Cation Transport Proteins

WebApr 10, 2024 · Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. ... This research was developed within the LAQV-REQUIMTE (UIDB/QUI/50006/2024) and Molecular Physical-Chemistry R & D Unit … how many calories in a timtamWebJul 1, 2024 · Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8]. how many calories in a tin of john west tunaWebApr 9, 1999 · 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce … how many calories in a timbitWebThe high stability of PTCG NPs during circulation stems from their strong metal-polyphenol coordination interactions, and efficient drug release is realized after cellular internalization. The activated cisplatin elevates the intracellular H 2 O 2 level through cascade reactions. how many calories in a tilapia filletWebIn addition to solubility limitations, cisplatin has also been shown to be a highly reactive molecule. The reactivity of cisplatin and other platinum complexes towards many … how many calories in a tin of corned beefWebThe microstructure and properties of metal ion-assisted cisplatin-loading SLNs were investigated by infra-red spectroscopy, fluorescence spectroscopy and zetasizer. The reactions of hydrogenated soybean lecithin with Zn(2+), Cu(2+), Mn(2+ )and Mg(2+ )have been detected; the mechanism for higher drug encapsulation efficiency (EE) has been ... how many calories in a timbiebWebIn water, the antineoplastic drug cisplatin, cis- [PtCl2 (NH3)2] (1) hydrolyses slowly to the aqua complexes cis- [Pt (NH3)2Cl (H2O)]+ (2) and, to a small extent, cis- [Pt (NH3)2 (H2O)2]2+ (3), which are thought to play an important role in the metabolism of cisplatin. high rise apartment austin