Clec9a ligand
WebMar 8, 2012 · CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells. In humans, this receptor is selectively expressed by BDCA3 + myeloid … WebThe natural ligand for CLEC9A is the intracellular cytoskeletal protein F-actin that becomes exposed on necrotic cells. In contrast to other C type lectins that signal through NF-κB and induce an inflammatory signature, CLEC9A signals through spleen tyrosine kinase (SYK) after F-actin binding.
Clec9a ligand
Did you know?
WebThe natural ligand for CLEC9A is the intracellular cytoskeletal protein F-actin that becomes exposed on necrotic cells. In contrast to other C type lectins that signal through NF-κB and induce an inflammatory signature, CLEC9A signals through spleen tyrosine kinase (SYK) after F-actin binding. WebMar 17, 2016 · The crystal structure of CLEC9A was reported in the apo form (PDB ID: 3VPP) (Zhang et al. 2012). The putative ligand recognition site of CLEC9A is similar to those of other CLRs. Two mutations located at this face, W131A and W227A, disrupt the ability to bind F-actin, supporting the idea that this face is a ligand recognition site.
WebApr 13, 2024 · CLEC9a (Ctype lectin domain family 9 member A), also known as DNGR1, is a type II transmembrane glycoprotein member of the Ctype lectin superfamily (1, 2). Mature human CLEC9a consists of a 35 amino acid (aa) cytoplasmic domain with an ITAMlike motif, a 21 aa transmembrane segment, and a 185 extracellular domain WebType 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8 + T cells. cDC1 cells can be identified in mice and …
WebDriving Directions to Tulsa, OK including road conditions, live traffic updates, and reviews of local businesses along the way. WebMar 7, 2012 · The damaged cell-recognition molecule Clec9A is expressed on the surface of the mouse and human dendritic cell subsets …
WebNov 19, 2024 · In Fawn Creek, there are 3 comfortable months with high temperatures in the range of 70-85°. August is the hottest month for Fawn Creek with an average high …
WebJun 13, 2008 · These data indicate that CLEC9A functions as an activation receptor. The C-type lectins are a superfamily of proteins containing at least one C-type lectin domain (CTLD), 2 which have been classified into groups depending on … help my anxiety is ruining my lifeWebMar 21, 2024 · CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 … land and associated real property craWebClec9A recognizes a conserved component within nucleated and nonnucleated cells, exposed when cell membranes are damaged. We have identi- fied this Clec9A ligand … help my amazon account has been hackedWebCLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008] ... check_circle Active Ligand: 0 . Tclin. Target has at least one approved drug - AND - satisfies the preceding conditions. check_circle ... help my baby poopWebDec 2, 2024 · Clec9A recognition of dead cells via binding to its ligand F-actin, requires conserved tryptophan residues located in the Clec9A … land and beyondWebIt recognizes a ubiquitous preformed acid-labile protein associated ligand (s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk. Product Details Technical data sheet Product Details Isotype Control help my baby has colicWebCD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the … help my back hurts