Cthrc1 gene

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August undefined, 2024

WebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ... WebCollagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene. Function. This locus encodes a protein that may play a role in the …

Cthrc1 Is a Novel Inhibitor of Transforming Growth Factor-β …

WebAug 7, 2024 · We reveal gene expression signatures that demarcate fibroblasts from mural cells and provide molecular signatures for cell subtype identification. ... C1qtnf3, and Cthrc1) their distribution in ... WebMar 1, 2024 · Expression of CTHRC1 in Patients With COAD Under Different Physiological or Pathological States. UALCAN analysis showed that the expression level of CTHRC1 was significantly higher in the patients with primary COAD than that in normal tissues ().Notably, this abnormally high expression pattern is generally applicable to patients with different … flag with seahorse

Frontiers CTHRC1 Is a Prognostic Biomarker and Correlated With …

WebAug 1, 2013 · Regulation of Cthrc1 gene expression by contact with hydroxyapatite and calcium. In order to gain further insight into the mechanism of Cthrc1 gene expression in osteoclasts, mature osteoclasts generated from BMMs ex vivo with M-CSF and RANKL were placed on different substrates, including a plastic dish, a dentin slice, or a … WebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found that it functionally increases cell migration while reducing collagen deposition. To address the in vivo role of Cthrc1, we generated transgenic mouse lines that constitutively overexpress … WebJun 15, 2024 · Gene expression of Cthrc1 was significantly increased from day 3, peaked at day 5, and fell back at day10 after injury (Fig. 1a). To verify this result, we examined the … flag with seal

DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman …

Cthrc1 MGI Mouse Gene Detail - MGI:1915838 - collagen triple …

WebSep 9, 2008 · Methodology/Principal Findings. We identified collagen triple helix repeat containing-1 (Cthrc1) as a downstream target of bone morphogenetic protein-2 (BMP2) in osteochondroprogenitor-like cells by PCR-based suppression subtractive hybridization followed by differential hybridization, and found that Cthrc1 was expressed in bone … Web屈振杰，崔琴. 内蒙古包钢医院1.肿瘤内科；2.消化内科，内蒙古包头 014010. 胃癌是消化道常见的恶性肿瘤，其发病率及死亡率居恶性肿瘤第2位[1]。 flag with serpentWebby Gene › by Protein › CTHRC1 Antibodies; CTHRC1 Antibodies . Antibodies that detect CTHRC1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and Immunoprecipitation. These antibodies target CTHRC1 in Human, Mouse and Rat samples. Our CTHRC1 polyclonal, … flag with shield and spears

"WebSep 21, 2011 · Orloff et al. (2011) identified a germline 131A-C transversion in exon 1 of the CTHRC1 gene, resulting in a gln44-to-pro (Q44P) substitution, in 1 (1.1%) of 116 patients of European descent with Barrett esophagus and/or esophageal adenocarcinoma ().The mutation was not found in 125 controls. The same mutation was found in 1 (1.7%) of 58 … " - Cthrc1 gene

Cthrc1 gene

JCI - Osteoclast-secreted CTHRC1 in the coupling of bone …

WebMar 21, 2024 · CTHRC1 serves as a pro-metastatic gene that contributes to NSCLC invasion and metastasis, which are mediated by upregulated MMP7 and MMP9 … WebOct 26, 2024 · The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics …

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WebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found that it functionally increases cell migration while reducing collagen deposition. To address the in vivo role of Cthrc1, we generated transgenic mouse lines that constitutively overexpress … WebMar 21, 2024 · CTHRC1 (Collagen Triple Helix Repeat Containing 1) is a Protein Coding gene. Diseases associated with CTHRC1 include Barrett Esophagus and Adenocarcinoma . Among its related pathways are Wnt …

WebOct 6, 2024 · According to the previous reports, the collagen triple helix repeat containing 1 (CTHRC1) causes tumorigenesis by modulating the tumor microenvironment, however, the evidence is limited to a few human cancer subtypes. ... (GEO) based datasets. During the analysis, we simply queue the CTHRC1 gene in these databases to acquire the KM … WebSep 23, 2024 · Through bioinformatics analyses and experiments, we confirmed that CTHRC1 is highly expressed in tissues and hepatoma cell lines. High expression of the CTHRC1 gene is associated with poor prognosis. Collectively, the results of the present study indicated that CTHRC1 may serve as a prognostic biomarker for HCC.

WebApr 10, 2024 · The analysis of the top 100 DEGs revealed that key genes regulating proinflammatory and immune responses (e.g., TREM2, CCL18, LAT2, and SLAMF7) as well as fibrogenesis and ECM remodeling (e.g., TIMP1, COL16A1, MMP14, CTHRC1, and ITGA11) were significantly downregulated, whereas PPARGC1A, a master regulator of …

WebJan 29, 2013 · Colorectal cancer (CRC) patients with peritoneal carcinomatosis (PC) have a poor prognosis. Over the last decade, increasing evidence has suggested that the Collagen Triple Helix Repeat Containing 1 (CTHRC1) gene is involved in cancer progression and invasion. In this study, we investigated the expression of CTHRC1 in CRC and its …

WebAug 30, 2024 · The occurence frequency of CTHRC1 gene is higher in multiple Wnt signaling pathway associated with enrichment classes. Furthemore, CTHRC1 gene is positively correlated with ANOS1. This implies that CTHRC1 probably plays an important role in the gene function/process of ANOS1. Many studies have investigated the role of … flag with shield in middleWebGenomic Mutations. 2 involving Cthrc1. Incidental Mutations. Mutagenetix , APF. Find Mice (IMSR) 20 strains or lines available. Comparison Matrix. Gene Expression + Phenotype. … canon rebel t6 cheat sheetWebCTHRC1 is known to regulate extracellular collagen deposition and partake in vascular remodeling of arterial injury as a function of cellular response through the TGF-β and Wnt pathways. Moreover, mutation of the gene has been associated with carcinogenesis in a variety of cell and tissues, most notably esophageal adenocarcinoma and Barrett ... canon rebel t6 dslr camera w/ 2 lens bundleWebMar 20, 2024 · The collagen triple helix repeat containing 1 (CTHRC1) gene is located on human chromosome 8q22.3 and was initially identified in balloon injury and normal rat … canon rebel t6 external monitorWebGene view. The gene view histogram is a graphical view of mutations across CTHRC1. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to ... flag with shovelWebAug 12, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and … canon rebel t6i battery and chargerWebCTHRC1 is a Potential Prognostic Biomarker and Correlated with Macrophage Infiltration in Breast Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Wang Z, Zhang S, Zheng C, Xia K, Sun L, Tang X, Zhou F, Ouyang Y, Tang F. Received 13 March 2024. flag with ship on it