Early growth response 1
EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice. See more The protein encoded by this gene belongs to the EGR family of Cys2His2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for … See more The DNA-binding domain of EGR-1 consists of three zinc finger domains of the Cys2His2 type. The amino acid structure of the EGR-1 zinc … See more EGR-1 has been shown to interact with: • CEBPB, • CREB-binding protein, • EP300, • NAB1, See more • Zif+268+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook Egr-1 See more EGR-1 binds the DNA sequence 5'-GCG TGG GCG-3' (and similar ones like 5'-GCG GGG GCG-3'). The f1 position 6 binds the 5' G (the first base count from the left); the f1 position 3 to the second base (C); f1 position -1 binds to the third position (G); f2 … See more • Zinc finger See more • Heath RG (March 1975). "Brain function and behavior. I. Emotion and sensory phenomena in psychotic patients and in experimental … See more WebEarly growth response (Egr)-1, 1 also known as NGFI-A, 2 zif268, 3 krox-24, 4 and TIS8 5, is a transcription factor and product of an immediate-early gene located on human chromosome 5q23-q31 encoding 2 exons. 1 The DNA binding domain of Egr-1 contains 3 zinc fingers of the Cys 2-His 2 subtype that bind preferentially to GC-rich elements. 6 Egr …
Early growth response 1
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WebEarly growth response (Egr)-1, 1 also known as NGFI-A, 2 zif268, 3 krox-24, 4 and TIS8 5, is a transcription factor and product of an immediate-early gene located on human … WebJul 18, 2024 · Early Growth Response Factor 1 in Aging Hematopoietic Stem Cells and Leukemia. Aging is associated with various hematological disorders and a higher risk of myeloproliferative disorders. An aged hematopoietic system can be characterized by decreased immune function and increased myeloid cell production. Hematopoietic stem …
WebIt has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, … WebEarly growth response 1 (EGR1) mediates transcriptional programs that are indispensable for cell division, differentiation, and apoptosis in numerous physiologies and …
WebEarly growth response-1 (Egr-1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our … WebMar 30, 2024 · One of the several host-factors that contribute to bacterial adhesion and the outcome of an infection is the activation of early growth response 1 (EGR1). EGR1 is …
Webthe VEGF gene (1). Another transcription factor that is upregulated by hypoxia is early growth response protein 1 (EGR1). EGR1 is part of a family of immediate early genes …
WebNov 10, 2024 · Early growth response‐1 (Egr‐1) is an immediate‐early gene that resides on human chromosome 5q23‐q31 and encodes a Cys … green new deal mileage taxWebJan 24, 2012 · The early growth response gene 1, EGR1, is an important transcriptional regulator and acts as the convergent point between a variety of extracellular stimuli and activation of target genes.Unlike other tumor types, prostate tumors express high levels of EGR1 relative to normal tissues. However, the mechanism of EGR1 regulation in … flylight adamWebJul 18, 2024 · Early growth response factor 1 (EGR1) is one of the key transcription factors controlling HSC proliferation and their localization in the bone marrow (BM) niche. … green new deal oda strategyWebFeb 23, 2024 · Background Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro … fly lift standWebEgr-1 is a member of the early growth response gene family like the c-fos and c-jun protooncogenes. Egr-1 expression is induced in many types of cells by various mitogenic stimuli or malignant transformation signals. The Egr-1 promoter is known to be transiently activated by ionizing radiation. fly lift airWebMar 13, 2024 · Early growth response factor 1 (Egr-1) is an early gene, belonging to the EGR family that codes for a Cys 2-His 2 zinc finger protein . It is located on human … green new deal nuclear powerWebEarly growth response transcription factor genes (Egr-1-Egr-4) and synaptic activity-inducible immediate early genes regulate some aspects of synaptic plasticity-related … flylight health