WebDownload scientific diagram Longevity of Xpc À/À G1-G3Terc À/À mouse model. from publication: Telomere Length and Telomerase Activity Impact the UV Sensitivity … WebMore recently, a study generated moderate cardiac-specific PGC1α OE through knocking into ROSA26 locus in WT mice and in mice with a G3Terc −/− (third generation of telomerase deficient; G3) background (Zhu et al., 2024). The G3 mice have decreased PGC1α levels and deficient basal and maximal mitochondrial function.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and ...
WebAug 15, 2024 · Methods and Results: Moderate cardiac-specific PGC1α overexpression through a ROSA26 locus knock-in strategy was utilized in WT (wild type) mice and in G3Terc −/− (third generation of telomerase deficient; hereafter as G3) mouse model, respectively. Ultrastructure, mitochondrial stress, echocardiographic, and a variety of … WebOpposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Ryan T. Wu,1,* Lei Cao,2 Elliot Mattson,1 Kenneth W. Witwer,3 Jay Cao,4 Huawei Zeng,4 Xin He,5 Gerald F. Combs Jr4,* and Wen-Hsing Cheng1,2 1Department of Nutrition and Food Science, University of Maryland, College Park, MD … free workplace agreement template
Telomeric epigenetic response mediated by Gadd45a regulates …
WebApr 20, 2024 · The third generation of telomerase-dysfunctional mice (refer as 'G3Terc-/-' or 'G3’) were originally gifted from Prof. Lenhard K. Rudolph. Young (2 months) and old (24 months) WT mice, and G3 mice were all maintained in a specific-pathogen-free facility with a 12 h light / 12 h dark cycle and food and water available ad libitum. WebJan 5, 2024 · Data show that loss of growth arrest and DNA-damage-inducible 45 alpha protein (Gadd45a) accelerates the onset of BCR-ABL driven leukemia in bone marrow recipient mice. by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a increases MEKK4 protein kinase activity, which is both sufficient to induce skeletal … fashion photography assistant jobs london