WebHIF1是具有螺旋-环-螺旋结构 (helix-loop-helix)的转录因子,可激活那些编码参与低氧稳态反应蛋白质的基因。 [1]。 举一个例子,如果肿瘤组织中的HIF1-α蛋白水平更高,代表它更缺氧。 侧面反应肿瘤组织更大。 缺氧与人类诸多重大疾病的病理生理都有关联,包括心肌和 … WebHIF-1 alpha是HIF-1蛋白亚基,由HIF1A基因编码。 HIF-1 alpha是细胞在缺氧条件下生存能力的重要转录调节因子。 HIF-1 alpha在血管形成中起重要作用,其失调与癌症和缺血性疾病病理学有关。 蛋白特性 HIF-1 alpha仅在含氧量低于5%的环境中稳定存在。 在正常含氧 …
HIF1A hypoxia inducible factor 1 subunit alpha [ (human)]
WebHIF-1α is a transcriptional factor encoded by the HIF1A gene located within chromosome 14q21-24 and is formed by 15 exons; HIF-1α consists of 826 amino acids and it has a molecular weight of 120 kDa. 48 48 Loboda A, Jozkowicz A, Dulak J. HIF-1 and HIF-2 transcription factors–similar but not identical. WebHIF-1α regulates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. grams in a ounce weight
基质细胞衍生因子-1_百度百科
Web30 de mar. de 2024 · HIF-1α has been recognized as an important cancer drug target . Hence, the HIF-1α inhibitor PX-478 was originally developed for cancer therapy and has been tested in clinical trials in patients with advanced solid tumors (67, 68). In the present study, we evaluated the potential of PX-478 as a new therapeutic agent to treat diabetes. Web7 de jul. de 1998 · Despite these findings, there is very little understanding of the steps underlying the activation of HIF-1 by hypoxia. Phosphorylation may be critical in the signaling process (4, 18), but there is no evidence thus far that HIF-1 phosphorylation is hypoxia-dependent.Binding of HSP90 with HIF-1α has been demonstrated in vitro (), and … WebHypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between elevated levels of HIF-1 and tumor metastasis, angiogenesis, poor patient prognosis as … chinatown detective agency library