Malat1 endothelial

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August undefined, 2024

Web8 feb. 2024 · lncRNA-MALAT1 promotes high glucose-induced H9C2 cardiomyocyte pyroptosis by downregulating miR-141-3p expression. ... Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res. 2014; 114:1389–1397. doi: … Web7 feb. 2024 · Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is an important member of the lncRNA family; it is approximately 8,700 nt in length and is localized to human chromosome 11q13.1. It belongs to intergenic lncRNA and is one of the most widely studied lncRNAs ( 4 ).

Long non-coding RNA MALAT1 plays a protective role in …

Web6 mrt. 2024 · Abstract. Stroke is one of the leading causes of death and long-term disability around the world. Angiogenesis is supposed to protect brain microvascular endothelial cells (BMECs) from oxidative and ischemic stress. Previous studies indicated that interaction between metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miR … Web16 dec. 2024 · In summary, MALAT1 suppression protects the endothelium from oxLDL-induced inflammation and oxidative stress in endothelial cells by upregulation of miR-181b and downregulation of TOX. 1. Introduction Atherosclerosis (AS), induced by plaque formation inside the arteries, is a lethal condition responsible for heart attack and stroke [ … cava benefits

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WebMetastasis-associatedlungadenocarcinomatranscript1 (MALAT1) is a widely investigated long noncoding RNA (lncRNA) and has been reported to be related with endo- thelial function [11–13]. Web6 okt. 2024 · MALAT1 knockdown significantly improved viability and suppressed the apoptosis of LPS-stimulated HPAEpiC. Moreover, MALAT1 directly targeted miR-194-5p, ... in VILI yet. Methods: To screen the differential expression of lncRNAs and mRNAs in Human pulmonary microvascular endothelial cells (HPMECs) subjected to cyclic stretch, ... Web18 jun. 2024 · MALAT1 and MIAT lncRNAs are associated with the angiogenesis process. MALAT1 induces hypoxia-driven angiogenesis via the overexpression of angiogenic genes. Down regulation of MIAT1 could inhibit the proliferation of … cava beach dubrovnik

LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to

RESEARCH Pioglitazone up-regulates MALAT1 and promotes the ...

http://www.antpublisher.com/index.php/APT/article/download/222/276 Web25 apr. 2024 · Here, we first determined the expression level of MALAT1 in human retinal microvascular endothelial cells (HRECs) cultured in high glucose (HG) and subsequently analyzed the expressions of... ca va bien je suisWeb13 okt. 2024 · The goal of this study is to investigate the role of LncRNA MALAT1 in the development of diabetic retinopathy, specifically in the regulation oxidative stress, via Keap1-Nrf2 interactions. Using human retinal endothelial cells (HRECs), we investigated the effect of high glucose on LncRNA MALAT1 expression and the regulation of LncRNA … cava bike tires

"WebExosomal MALAT1 derived from oxidized low-density lipoprotein-treated endothelial cells promotes M2 macrophage polarization. Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous … " - Malat1 endothelial

Malat1 endothelial

LncRNA MALAT1 Suppression Protects Endothelium against oxLDL …

Web14 okt. 2024 · MALAT1 is one of the most abundant lncRNAs in platelets. However, the functional roles of MALAT1 in platelets are unexplored. What this study adds In this study, the function of MALAT1 in platelets was investigated in vitro and in vivo. WebMALAT1, also known as nuclear-enriched autosomal transcript 2 (NEAT2), is 8,708 bp in length (NR_002819.2). The gene is located on chromosome 11q13.1 and is expressed in almost all human and murine tissue cells, but its expression is most prominent in the nervous system [3].

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Web10 sep. 2024 · Background . Endothelial dysfunction commonly occurs in obese children and adolescents, leading to an increased risk of cardiovascular diseases. Exercise has significant protective effects against endothelial dysfunction through regulating some noncoding RNAs. This study aimed to investigate the relationship of long noncoding RNA … Web15 jan. 2024 · study [13], and MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was involved in the proliferation of endothelial cells and associated with the progression of cardiovascular diseases [14]. At the same time, the antisense transcript of GATA6 (GATA6-AS) is involved in endothelial cell (EC) migration and has a repressive …

Webpaper showed that MALAT1 controls a phenotypic switch in endothelial cell and regulates its function and vessel growth [18]. It has also been demonstrated that MALAT1 plays a pathogenic role in endothelial cell dysfunction in diabetes mellitus [19]. However, whether MALAT1 is in-volved in regulating EPC function in T2DM remains un-known. WebLncRNA MALAT1 Promotes STAT3-Mediated Endothelial Inflammation by Counteracting the Function of miR-590. The excessive production of inflammatory mediators by vascular endothelial cells (ECs) greatly contributes to the development of atherosclerosis.

Web13 apr. 2024 · 经国家自然科学基金委员会监督委员会五届十六次会议审议、国家自然科学基金委员会2024年第2次委务会议审定，决定依据《国家自然科学基金项目科研不端行为调查处理办法》（国科金发诚〔2024〕96号）第四十七条、第四十条、第四十六条，撤销张亚东国 … Web4 feb. 2024 · Then, MALAT1 acts as a sponge for miR-384, thus enhancing the transcription level of oncogene mal T-cell differentiation protein 2 (MAL2) and ultimately promoting bladder cancer growth. In accordance with previous findings, the clinical expression levels of FTO, MALAT, miR-384 and MAL2 were collected; the results also showed a strong …

WebEndothelial-specific overexpression of MYC was sufficient to induce type H bone endothelial cells, ... In this study, the effect of the lncRNA …

Web21 mei 2024 · MALAT1 and miR-205-5p were both significantly upregulated in the serum of CIS patients and HBMECs under OGD/R, and the tube formation of HBMECs was damaged after OGD/R treatment. Silencing miR-205-5p remarkably promoted HBMEC … cava bevandaWeb25 apr. 2014 · MALAT1 was significantly increased by hypoxia and controls a phenotypic switch in endothelial cells. Silencing of MALAT1 by small interfering RNAs or GapmeRs induced a promigratory response and increased basal sprouting and migration, whereas proliferation of endothelial cells was inhibited. cava bkaWeb5 feb. 2024 · Recently, MALAT1 was identified as a pyroptosis-related long noncoding RNA (lncRNA). Here, we investigated the potential role and underlying mechanism of lncRNA MALAT1 in endothelial cells pyroptosis. We first established an endothelial cell … cava bikeWebMALAT1 is associated with vascular endothelial cell homeostasis , and reduced MALAT1 expression may impede vascular repair after SARS-CoV-2 infection. MT-CO1 (ENSG00000198804), as a second parameter, was downregulated in vascular endothelial cells after SARS-CoV-2 infection in this rule. cava bistroWeb3 jan. 2024 · Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA contributing to protect the blood–brain barrier (BBB) after stroke. We searched for small molecules that may up-regulate MALAT1 and focused on polydatin (PD), a natural product, as a possible candidate. PD enhanced MALAT1 gene expression in … cava blaWebObjectives: Maturation of dendritic cells (DCs) contributes to atherosclerosis (AS) development. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that is involved in tumorigenesis. This study was … cava blackmon driveWeb13 sep. 2024 · In the present study, we investigated the following: i) MALAT1 expression in BC tissues; ii) the role of MALAT1 in the regulation of microvascular endothelial cell proliferation, migration, and tube formation of BC in vitro using the RNA interference approach; iii) the effect of MALAT1 on angiogenesis by VEGF; and iv) preliminary … cava bolsa