Web14 ott 2024 · However, PRODIGE 23 did not test a true TNT strategy, given that participants in the TNT arm received a protocol-specified six cycles of adjuvant FOLFOX or capecitabine. FOLFIRINOX was also used only in the TNT arm, and thus the improved outcome may in part reflect the addition of irinotecan rather than therapy sequencing. WebPRODIGE 13 1 is a prospective multicentre controlled trial evaluating by double randomisation the impact of i) intensive radiological monitoring (CT-scan/6m) versus a standard one (abdominal ultrasound/3m and thoracic radiography/6m) and ii) CEA assessment versus no, in the follow-up of resected stage II or III CRC with no evidence …

Patologia gastrointestinale - Tumore del retto e Total …

WebThus, the RAPIDO and PRODIGE 23 phase III randomized clinical trials have recently shown that the addition of neoadjuvant chemotherapy to a standard short-or long-course radiation significantly ... Web1 mag 2024 · A few months ago, results from two randomised phase III trials of total neoadjuvant therapy (TNT) in locally advanced rectal cancer were presented (RAPIDO … kia seltos official website india

Comparison of the outcomes of the RAPIDO [13] and PRODIGE 23 …

WebThis trial randomised 231 patients with rectal adenocarcinoma and high risk features such as cT3/cT4 disease, to receive six cycles of mFOLFIRINOX, followed by five weeks of chemoradiation, TME and a further six cycles of mFOLFOX or four cycles of capecitabine or a control regimen consisting of standard chemoradiation, followed by TME and twelve … WebPRODIGE-23 compared 12 cycles of modified FOLFIRINOX followed by CRT, surgery and 4 cycles of capecitabine or 6 cycles of modified FOLFOX6 adjuvant chemotherapy with CRT, followed by surgery... Web5 mar 2013 · 1600 mg/m² (800 mg/m² twice daily) for 5 weeks. Procedure: TME surgery. Drug: mFolfox6 or capecitabine. oxaliplatine 85 mg/m² (day 1 of cycle; perfusion in 2h), … kia seltos maintenance schedule